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Such interactions can elevate or reduce the amount of drug in the body, increase the risk of side effects, and may even be life-threatening. Eating grapefruit with some medications used to treat high cholesterol can make the level of drug in your body higher. Using certain medications to ease a stuffy nose could raise blood glucose.
Many people with diabetes also have other chronic problems, such as high blood pressure, high cholesterol, nerve pain (neuropathy), and depression. Since several chronic conditions are being managed at the same time, a drug interaction is possible. However, educating yourself can reduce your risk of experiencing harmful drug interactions and side effects. Your pharmacist is a medication expert who is also available to answer any of your questions.
OTC Medication Guideline for Those with DiabetesProducts listed here include only a partial list of those available in each OTC category. If you are considering a product, please ask your pharmacist or doctor about the potential for drug interactions. |
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| Analgesics and Antipyretics – used for aches, pain and fever. | |||||
| Acetaminophen e.g. Tylenol™ | Safest | ||||
| ASA e.g. Aspirin™ | Safe, in low doses. (Often taken as a preventive measure for heart disease.) High doses can cause hypoglycemia (low blood glucose). | ||||
| Ibuprofen e.g. Advil™, Motrin™ | Belongs to a group of medications called non-steroidal anti-inflamatories (NSAIDs). Can cause blood glucose to increase if used long term in large doses. Should be used with caution by people with decreased kidney function, as it may negatively affect kidney function. A drug called naproxen, available in a non-prescription strength in the United States under the trade name Aleve™, also belongs to this family. | ||||
| Antidiarrheals* – used to relieve diarrhea. | |||||
| Loperamide e.g. Imodium™ | Safe for short duration (less than 24 hours).. | ||||
| Bismuth subsalicylate e.g. Pepto-Bismol™ | Avoid if possible due to salicylate content (can increase the risk of low blood glucose). Can decrease absorption of other medications if taken with them. | ||||
| Attapulgite e.g. Kaopectate™ | Appears safe to use short term. Note: in the United States, Kaopectate has been re-formulated to contain bismuth subsalicylate instead of attapulgite and so is not recommended for use by people with diabetes. |
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| Antiemetic* – used for nausea and vomiting. | |||||
| Dimenhydrinate e.g. Gravol™ | No known drug interactions with diabetes or diabetes medication. * People with diabetes must be aware that the risk of dehydration increases with persistent or explosive diarrhea and/or vomiting. Check blood glucose more often. Check for ketones. Be sure to have a ‘sick day’ management plan in place and ensure fluid replacement. |
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| Antacids – used for heartburn, indigestion and esophageal reflux. Antiflatulants – used for gas. |
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Magnesium hydroxide e.g. Maalox™ |
Can increase the risk of low blood glucose by increasing the concentration of certain diabetes medication in the body. |
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| Calcium carbonate e.g. Tums™ | Can alter the absorption of other medications. Take at least three hours after other medications. Monitor blood glucose carefully when starting or stopping. | ||||
| Can alter the absorption of other medications. Take at least three hours after other medications. Monitor blood glucose carefully when starting or stopping. | |||||
H2 Antagonists - |
Can increase the risk of low blood glucose by increasing concentrations of certain diabetes medication in the body. |
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| Simethicone e.g. Ovol™, Gas-X™ | Appears safe for people with diabetes to use. | ||||
| Laxatives – used for constipation, a common long-term complication of diabetes due to nerve damage. | |||||
| Docusate sodium e.g. Colace™ | No known interactions with diabetes. | ||||
| Docusate calcium e.g. Surfak™ | Can be used with diabetes. | ||||
| Sennosides e.g. Senekot™ | No known interactions with diabetes. | ||||
| Bisacodyl e.g. Dulcolax™ | Can be used short term. Has a harsher effect. | ||||
| Psyllium e.g. Metamucil™ | Useful for those with diabetes. Adds fibre content to diet as well as helping with constipation. Use a sugar-free product and watch sodium content. |
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Cough, Cold and Allergies |
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| Antihistamines – used to treat symptoms of runny nose, watery eyes and sneezing. Typically found in allergy medication, such as: | |||||
Chlorpheniramine e.g. Chlor-Tripolon™ |
No effect on blood glucose. | ||||
| Expectorants – used to loosen chest mucus and make cough more productive. | |||||
| Guaifenesin e.g. Robitussin™ | No effect on blood glucose control. | ||||
| Antitussives – used to stop cough. | |||||
| Dextromethorphan e.g. Delysm™ DM Codeine e.g. Robitussin™ with codeine |
No significant effect on blood glucose. | ||||
Decongestants – used to relieve nasal stuffiness associated with the common cold or allergies. Available as tablets to |
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Oral tablets, such as: |
Use with caution, have the potential to increase blood glucose | ||||
Nasal sprays, such as: |
Use only short-term (maximum five days) to avoid congestion rebound. Use with caution, can also increase blood glucose. Risk to increase blood glucose is less since effect is local. |
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| saline solution eg. Salinex™ | Safe to use. Little risk of rebound congestion. Doesn’t appear to affect blood glucose. Useful as a nasal moisturizer. | ||||
Herbals |
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Remember that, in general, ‘sick days’ are associated with changing blood glucose levels. This could be related to the stress of being sick or changes in diet. Following these tips when feeling ill may help.
When looking for over-the-counter products (OTCs) to relieve symptoms, remember the following:
Whenever you start any new prescription or OTC medication, whether for diabetes or another problem, it is important to monitor your blood glucose more closely. Additional monitoring allows you to know how the new medication is affecting you. Ideally, you should know your usual blood glucose values before you start a new medication. Once you have begun your new medication, do a similar testing pattern and compare your results. You and your health care provider are now able to see any effect the new medication has on your blood glucose levels. Each person reacts differently to medication and medication combinations.
Now, how can we help Mrs. Green decide what is right for her husband? The pharmacist will ask questions that can help decide if medication is necessary, and choose the right one.
By discussing these issues with the pharmacist, hopefully Mrs. Green will learn more about dealing with sickness and her husband’s diabetes. With help, she is able to make a wise choice for her husband. Knowledge, common sense, and increased monitoring of blood glucose goes a long way towards avoiding potential problems when self medicating. When in doubt, always ask your pharmacist!
Articles in the Diabetes section of Family Health OnLine are sponsored by:
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